Protective Effect of Trimetazidine on Kidney Dysfunction: A Review of Experimental Evidence

Document Type : Original article


1 Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

2 The Persian Gulf Physiology Research Center, Medical Basic Sciences Research Institute, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.


Background and Objectives Acute kidney injury is the main cause of morbidity and
mortality in the worldwide that is accompanied by short-term and long-term complications,
including chronic kidney disease, end-stage renal disease, and ultimately death. Various
mechanisms are involved in renal dysfunction, including oxidative stress, inflammatory
responses, apoptosis, fibrosis, and mitochondrial dysfunction. Trimetazidine as a drug with
free radical oxygen scavenging property represents to be more invaluable against acute
kidney injury. Trimetazidine is considered as an anti-ischemic drug in the treatment of
cardiac diseases which has been documented pharmacologic effects such as antioxidant,
anti-apoptotic, and anti-inflammatory properties in renal ischemia-reperfusion injury,
diabetic nephropathy, and nephrotoxicity models.
Subjects and Methods This review underlines the nephroprotective effect of
trimetazidine on kidney injury models. For this review, the articles have been searched in
the databases, including PubMed, Scopus, Web of science, and Google Scholar. The search
process was provided using these keywords: “Trimetazidine”, “kidney”, “nephrotoxicity”,
“renal ischemia – reperfusion injury”, and “Protective.”
Results Present study validates which trimetazidine as a potential agent alleviates kidney
dysfunction in experimental models through several mechanisms.
Conclusion Trimetazidine could be considered as promising candidate to treat a variety
of kidney diseases in the future.