Antidepressant Effect of Hydroalcoholic Extract of Quercus Brantii and Oil of Quercus Brantii on a Rat Model of Postpartum Depression

Document Type : Original article


1 Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

2 Department of Biochemistry, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.


Background and Objectives One of the most common complications after childbirth is
postpartum depression (PPD), a major depressive disorder. The aim of this study was to
investigate the effects of the hydroalcoholic extract and oil of Quercus brantii as an
experimental model of PPD in rats.
Subjects and Methods 42 adult female Wistar rats in six groups were used in this study.
All animals received daily progesterone injections at a dose of 5 mg/kg intraperitoneally for
5 consecutive days. A hydroalcoholic extract of Quercus brantii (100mg/kg) and oil (45%)
were administered simultaneously with PPD modeling by progesterone withdrawal. On day
8, depressive behavior was then assessed by a forced swim test. To investigate the role of
the oxidant-antioxidant system, reduced glutathione (GSH), catalase, superoxide dismutase
(SOD) and malondialdehyde (MDA) have been assessed after the last injection.
Results Statistical analysis showed that progesterone induced significant immobilization
in the control group receiving saline (P<0.001) and in the vehicle group receiving sesame oil
(P<0.001). The administration of hydroalcoholic oak extract (100 mg/kg) shortened the
immobility time compared to the control group (P<0.05). The results of this study show
that depression has no effect on locomotor activity. The hydroalcoholic extract of Quercus
brantii (100mg/kg) significantly improved depression, decreased MDA and increased SOD.
On the other hand, Quercus brantii oil (45%) has no significant effect on depression, but
lowers MDA and increases catalase.
Conclusion Q. brantii appears to be a natural source of antidepressant compounds that
increase antioxidant levels, which is currently being investigated by our group.